TargetMol

BIA 3-335

Product Code:
 
TAR-T26797
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26797-5mg5mg£850.00
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TAR-T26797-50mg50mg£1,661.00
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Quantity:
TAR-T26797-100mg100mg£2,079.00
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Further Information

Bioactivity:
BIA 3-335, an inhibition of catechol-O-methyltransferase, could have applications for Parkinson's Disease.
CAS:
359783-06-5
Formula:
C20H22Cl2F3N3O5
Molecular Weight:
512.31
Purity:
0.98
SMILES:
Cl.Cl.Oc1cc(cc(c1O)[N+]([O-])=O)C(=O)CCN1CCN(CC1)c1cccc(c1)C(F)(F)F

References

1. Bonif?cio MJ, Archer M, Rodrigues ML, Matias PM, Learmonth DA, Carrondo MA, Soares-Da-Silva P. Kinetics and crystal structure of catechol-o-methyltransferase complex with co-substrate and a novel inhibitor with potential therapeutic application. Mol Pharmacol. 2002 Oct;62(4):795-805. PubMed PMID: 12237326. 2. Learmonth DA, Palma PN, Vieira-Coelho MA, Soares-da-Silva P. Synthesis, biological evaluation, and molecular modeling studies of a novel, peripherally selective inhibitor of catechol-O-methyltransferase. J Med Chem. 2004 Dec 2;47(25):6207-17. PubMed PMID: 15566291. 3. Learmonth DA, Bonif?cio MJ, Soares-da-Silva P. Synthesis and biological evaluation of a novel series of "ortho-nitrated" inhibitors of catechol-O-methyltransferase. J Med Chem. 2005 Dec 15;48(25):8070-8. PubMed PMID: 16335931. 4. Rodrigues ML, Archer M, Bonif?cio MJ, Soares-da-Silva P, Carrondo MA. Crystallization and preliminary crystallographic characterization of catechol-O-methyltransferase in complex with its cosubstrate and an inhibitor. Acta Crystallogr D Biol Crystallogr. 2001 Jun;57(Pt 6):906-8. Epub 2001 May 25. PubMed PMID: 11375525.