TargetMol

Bicyclomycin

Product Code:
 
TAR-T26805
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T26805-5mg5mgEnquire
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Further Information

Bioactivity:
Bicyclomycin is a broad spectrum antibiotic active against Gram-negative bacteria and the Gram-positive bacterium, Micrococcus luteusn.
CAS:
38129-37-2
Formula:
C12H18N2O7
Molecular Weight:
302.283
Purity:
0.98
SMILES:
CC(O)(CO)[C@@H](O)C12NC(=O)[C@](O)(NC1=O)C(=C)CCO2

References

1. Tran L, van Baarsel JA, Washburn RS, Gottesman ME, Miller JH. Single-gene deletion mutants of Escherichia coli with altered sensitivity to bicyclomycin, an inhibitor of transcription termination factor Rho. J Bacteriol. 2011 May;193(9):2229-35. doi: 10.1128/JB.01463-10. Epub 2011 Feb 25. PubMed PMID: 21357484; PubMed Central PMCID: PMC3133090. 2. Weber TP, Widger WR, Kohn H. The Mg2+ requirements for rho transcription termination factor: catalysis and bicyclomycin inhibition. Biochemistry. 2002 Oct 15;41(41):12377-83. PubMed PMID: 12369827. 3. Tanaka N, Iseki M, Miyoshi T, Aoki H, Imanaka H. Mechanism of action of bicyclomycin. J Antibiot (Tokyo). 1976 Feb;29(2):155-68. PubMed PMID: 776917. 4. Someya A, Iseki M, Tanaka N. Active groups of bicyclomycin and the reaction with thiols. J Antibiot (Tokyo). 1979 Apr;32(4):402-7. PubMed PMID: 38239.