TargetMol

BMS 182874

Product Code:
 
TAR-T26841
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26841-1mg1mg£139.00
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TAR-T26841-5mg5mg£231.00
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TAR-T26841-10mg10mg£336.00
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TAR-T26841-25mg25mg£518.00
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TAR-T26841-50mg50mg£699.00
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TAR-T26841-100mg100mg£946.00
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Quantity:
TAR-T26841-500mg500mg£1,862.00
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Further Information

Bioactivity:
BMS 182874 is an endothelin receptor antagonist with antihypertensive activity.
CAS:
153042-42-3
Formula:
C17H19N3O3S
Molecular Weight:
345.42
Pathway:
GPCR/G Protein
Purity:
0.98
SMILES:
CN(C)c1cccc2c(cccc12)S(=O)(=O)Nc1onc(C)c1C
Target:
Endothelin Receptor

References

1. Stein PD, Hunt JT, Floyd DM, Moreland S, Dickinson KE, Mitchell C, Liu EC, Webb ML, Murugesan N, Dickey J, et al. The discovery of sulfonamide endothelin antagonists and the development of the orally active ETA antagonist 5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulf onamide. J Med Chem. 1994 Feb 4;37(3):329-31. PubMed PMID: 8308857. 2. Piovezan AP, D'Orl?ans-Juste P, Tonussi CR, Rae GA. Effects of endothelin-1 on capsaicin-induced nociception in mice. Eur J Pharmacol. 1998 Jun 12;351(1):15-22. PubMed PMID: 9698200. 3. Park JB, Schiffrin EL. Cardiac and vascular fibrosis and hypertrophy in aldosterone-infused rats: role of endothelin-1. Am J Hypertens. 2002 Feb;15(2 Pt 1):164-9. PubMed PMID: 11863252. 4. Scherer EQ, Herzog M, Wangemann P. Endothelin-1-induced vasospasms of spiral modiolar artery are mediated by rho-kinase-induced Ca(2+) sensitization of contractile apparatus and reversed by calcitonin gene-related Peptide. Stroke. 2002 Dec;33(12):2965-71. PubMed PMID: 12468798.