TargetMol

BMS-814580

Product Code:
 
TAR-T26860
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26860-5mg5mg£1,091.00
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TAR-T26860-50mg50mg£2,143.00
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Quantity:
TAR-T26860-100mg100mg£2,801.00
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Further Information

Bioactivity:
BMS-814580 is a potent and selective functional antagonist (Kb = 117 nM) of human MCHR1. BMS-814580 exhibits potent binding affinity (Ki = 17 nM) for human MCHR1. BMS-814580 also exhibits potent binding affinities for cynomolgus monkey and rat MCHR1 (Ki of 4.9 and 11.5 nM, respectively). MCHR1 antagonist demonstrates reduction in feeding and body weight in rats and mice.
CAS:
1197420-11-3
Formula:
C24H19ClF2N2O4S
Molecular Weight:
504.93
Purity:
0.98
SMILES:
COc1cc(ccc1OCC1(O)CC(F)(F)C1)-n1cnc2cc(sc2c1=O)-c1ccc(Cl)cc1

References

1. Ahmad S, Washburn WN, Hernandez AS, Bisaha S, Ngu K, Wang W, Pelleymounter MA, Longhi D, Flynn N, Azzara AV, Rohrbach K, Devenny J, Rooney S, Thomas MA, Glick S, Godonis H, Harvey S, Zhang H, Gemzik B, Janovitz EB, Huang C, Zhang L, Robl JA, Murphy BJ. Synthesis and Anti-obesity Properties of 6-(4-Chlorophenyl)-3-(4-((3,3-difluoro-1-hydroxycyclobutyl)methoxy)-3-methoxyphen yl)thieno[3,2-d]pyrimidin-4(3H)-one (BMS-814580): A Highly Efficacious Melanin Concentrating Hormone Receptor-1 (MCHR1) Inhibitor. J Med Chem. 2016 Aug 26. [Epub ahead of print] PubMed PMID: 27564419.