TargetMol

BMVC4

Product Code:
 
TAR-T26872
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26872-5mg5mg£850.00
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This product comes from: United States.
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Further Information

Bioactivity:
BMVC4 is a G-quadruplex stabilizer. BMVC4 induces senescence by activation of pathways of response to DNA damage that was independent of its telomerase inhibitory activity.
CAS:
850559-53-4
Formula:
C26H23I2N5
Molecular Weight:
659.314
Purity:
0.98
SMILES:
[I-].[I-].C[n+]1ccncc1C=Cc1ccc2[nH]c3ccc(C=Cc4cncc[n+]4C)cc3c2c1

References

1. Wang JM, Huang FC, Kuo MH, Wang ZF, Tseng TY, Chang LC, Yen SJ, Chang TC, Lin JJ. Inhibition of cancer cell migration and invasion through suppressing the Wnt1-mediating signal pathway by G-quadruplex structure stabilizers. J Biol Chem. 2014 May 23;289(21):14612-23. doi: 10.1074/jbc.M114.548230. Epub 2014 Apr 8. PubMed PMID: 24713700; PubMed Central PMCID: PMC4031517. 2. Huang FC, Chang CC, Wang JM, Chang TC, Lin JJ. Induction of senescence in cancer cells by the G-quadruplex stabilizer, BMVC4, is independent of its telomerase inhibitory activity. Br J Pharmacol. 2012 Sep;167(2):393-406. doi: 10.1111/j.1476-5381.2012.01997.x. PubMed PMID: 22509942; PubMed Central PMCID: PMC3481046.