TargetMol

BRL 44408 Maleate Salt

Product Code:
 
TAR-T26904
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26904-5mg5mg£850.00
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TAR-T26904-50mg50mg£1,661.00
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Quantity:
TAR-T26904-100mg100mg£2,079.00
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Further Information

Bioactivity:
BRL 44408 Maleate Salt is a selective α2A-adrenoceptor antagonist with Ki value of 1.7 nM. BRL 44408 Maleate Salt increases the release of hippocampal noradrenalin following systemic administration.
CAS:
681806-46-2
Formula:
C17H21N3O4
Molecular Weight:
331.372
Purity:
0.98
SMILES:
OC(=O)C=C/C(O)=O.CC1N(CC2=NCCN2)Cc2ccccc12

References

1. Dwyer JM, Platt BJ, Rizzo SJ, Pulicicchio CM, Wantuch C, Zhang MY, Cummons T, Leventhal L, Bender CN, Zhang J, Kowal D, Lu S, Rajarao SJ, Smith DL, Shilling AD, Wang J, Butera J, Resnick L, Rosenzweig-Lipson S, Schechter LE, Beyer CE. Preclinical characterization of BRL 44408: antidepressant- and analgesic-like activity through selective alpha2A-adrenoceptor antagonism. Int J Neuropsychopharmacol. 2010 Oct;13(9):1193-205. doi: 10.1017/S1461145709991088. PubMed PMID: 20047711. 2. Meana JJ, Callado LF, Pazos A, Grijalba B, Garc?a-Sevilla JA. The subtype-selective alpha 2-adrenoceptor antagonists BRL 44408 and ARC 239 also recognize 5-HT1A receptors in the rat brain. Eur J Pharmacol. 1996 Oct 3;312(3):385-8. PubMed PMID: 8894622.