TargetMol

Bufuralol HCl

Product Code:
 
TAR-T26921
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26921-5mg5mg£1,091.00
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TAR-T26921-50mg50mg£2,143.00
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TAR-T26921-100mg100mg£2,801.00
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This product comes from: United States.
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Further Information

Bioactivity:
Bufuralol is a β-adrenoceptor antagonist with partial agonist activity.
CAS:
59652-29-8
Formula:
C16H24ClNO2
Molecular Weight:
297.82
Purity:
0.98
SMILES:
Cl.CCc1cccc2cc(oc12)C(O)CNC(C)(C)C

References

1. Cai J, Dai DP, Geng PW, Wang SH, Wang H, Zhan YY, Huang XX, Hu GX, Cai JP. Effects of 22 Novel CYP2D6 Variants Found in the Chinese Population on the Bufuralol and Dextromethorphan Metabolisms In Vitro. Basic Clin Pharmacol Toxicol. 2016 Mar;118(3):190-9. doi: 10.1111/bcpt.12478. Epub 2015 Sep 26. PubMed PMID: 26310775. 2. Uehara S, Uno Y, Hagihira Y, Murayama N, Shimizu M, Inoue T, Sasaki E, Yamazaki H. Marmoset cytochrome P450 2D8 in livers and small intestines metabolizes typical human P450 2D6 substrates, metoprolol, bufuralol and dextromethorphan. Xenobiotica. 2015;45(9):766-72. doi: 10.3109/00498254.2015.1019595. Epub 2015 Jul 27. PubMed PMID: 25801057. 3. Johnston EV, Bog?r K, B?ckvall JE. Enantioselective synthesis of (R)-bufuralol via dynamic kinetic resolution in the key step. J Org Chem. 2010 Jul 2;75(13):4596-9. doi: 10.1021/jo100936f. PubMed PMID: 20524620. 4. Uno Y, Uehara S, Kohara S, Murayama N, Yamazaki H. Cynomolgus monkey CYP2D44 newly identified in liver, metabolizes bufuralol, and dextromethorphan. Drug Metab Dispos. 2010 Sep;38(9):1486-92. doi: 10.1124/dmd.110.033274. Epub 2010 May 25. PubMed PMID: 20501912.