TargetMol

Cazpaullone

Product Code:
 
TAR-T26959
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T26959-5mg5mg£850.00
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Quantity:
TAR-T26959-50mg50mg£1,661.00
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Quantity:
TAR-T26959-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
Cazpaullone is an inhibitor of glycogen synthase kinase-3 (GSK-3). It also shows transient stimulation of the mRNA expression of the beta cell transcription factor Pax4.
CAS:
914088-64-5
Formula:
C16H10N4O
Molecular Weight:
274.283
Purity:
0.98
SMILES:
O=C1Cc2c([nH]c3ccc(cc23)C#N)-c2ncccc2N1

References

1. Regan CP, Stump GL, Wallace AA, Anderson KD, McIntyre CJ, Liverton NJ, Lynch JJ Jr. In vivo cardiac electrophysiologic and antiarrhythmic effects of an isoquinoline IKur blocker, ISQ-1, in rat, dog, and nonhuman primate. J Cardiovasc Pharmacol. 2007 Apr;49(4):236-45. PubMed PMID: 17438409. 2. Regan CP, Kiss L, Stump GL, McIntyre CJ, Beshore DC, Liverton NJ, Dinsmore CJ, Lynch JJ Jr. Atrial antifibrillatory effects of structurally distinct IKur blockers 3-[(dimethylamino)methyl]-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one and 2-phenyl-1,1-dipyridin-3-yl-2-pyrrolidin-1-yl-ethanol in dogs with underlying heart failure. J Pharmacol Exp Ther. 2008 Jan;324(1):322-30. Epub 2007 Oct 29. PubMed PMID: 17967939.