TargetMol

Crebinostat

Product Code:
 
TAR-T27083
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27083-1mg1mg£352.00
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TAR-T27083-5mg5mg£736.00
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TAR-T27083-10mg10mg£978.00
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TAR-T27083-25mg25mg£1,348.00
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TAR-T27083-50mg50mg£1,661.00
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TAR-T27083-100mg100mg£2,079.00
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Quantity:
TAR-T27083-500mg500mg£4,006.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
Crebinostat is an inhibitor of HDACs 1-3 and 6. Crebinostat induces histone acetylation, regulates neuronal genes involved in synaptic function and cognition, enhances performance in fear conditioning learning in mice.
CAS:
1092061-61-4
Formula:
C20H23N3O3
Molecular Weight:
353.422
Pathway:
Chromatin/Epigenetic|DNA Damage/DNA Repair
Purity:
0.98
SMILES:
ONC(=O)CCCCCC(=O)NN=Cc1ccc(cc1)-c1ccccc1
Target:
Histone Acetyltransferase|HDAC|Epigenetic Reader Domain

References

1. Ghosh B, Zhao WN, Reis SA, Patnaik D, Fass DM, Tsai LH, Mazitschek R, Haggarty SJ. Dissecting structure-activity-relationships of crebinostat: Brain penetrant HDAC inhibitors for neuroepigenetic regulation. Bioorg Med Chem Lett. 2016 Feb 15;26(4):1265-1271. doi: 10.1016/j.bmcl.2016.01.022. Epub 2016 Jan 11. PubMed PMID: 26804233; PubMed Central PMCID: PMC4753070. 2. Fass DM, Reis SA, Ghosh B, Hennig KM, Joseph NF, Zhao WN, Nieland TJ, Guan JS, Kuhnle CE, Tang W, Barker DD, Mazitschek R, Schreiber SL, Tsai LH, Haggarty SJ. Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity. Neuropharmacology. 2013 Jan;64:81-96. doi: 10.1016/j.neuropharm.2012.06.043. Epub 2012 Jul 4. PubMed PMID: 22771460; PubMed Central PMCID: PMC3447535.