TargetMol

Crobenetine hydrochloride

Product Code:
 
TAR-T27086
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27086-5mg5mg£1,171.00
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TAR-T27086-50mg50mg£2,303.00
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TAR-T27086-100mg100mg£3,042.00
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Further Information

Bioactivity:
Crobenetine hydrochloride, a sodium channel antagonist, is used potentially for the treatment of stroke.
CAS:
221018-88-8
Formula:
C25H34ClNO2
Molecular Weight:
416
Purity:
0.98
SMILES:
Cl.[H][C@]12Cc3c(O)cccc3[C@](C)(CCN1C[C@H](C)OCc1ccccc1)C2(C)C

References

2. Grauert M, Bechtel WD, Weiser T, Stransky W, Nar H, Carter AJ. Synthesis and structure-activity relationships of 6,7-benzomorphan derivatives as use-dependent sodium channel blockers for the treatment of stroke. J Med Chem. 2002 Aug 15;45(17):3755-64. PubMed PMID: 12166948. 1: Meythaler J. BIII-890-CL. Boehringer Ingelheim. Curr Opin Investig Drugs. 2002 Dec;3(12):1733-5. Review. PubMed PMID: 12528308. 3. Carter AJ, Grauert M, Pschorn U, Bechtel WD, Bartmann-Lindholm C, Qu Y, Scheuer T, Catterall WA, Weiser T. Potent blockade of sodium channels and protection of brain tissue from ischemia by BIII 890 CL. Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4944-9. PubMed PMID: 10781102; PubMed Central PMCID: PMC18337. 4. Dekker LV, Daniels Z, Hick C, Elsegood K, Bowden S, Szestak T, Burley JR, Southan A, Cronk D, James IF. Analysis of human Nav1.8 expressed in SH-SY5Y neuroblastoma cells. Eur J Pharmacol. 2005 Dec 28;528(1-3):52-8. PubMed PMID: 16325806.