TargetMol

Cryptopleurine

Product Code:
 
TAR-T27091
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27091-5mg5mg£1,653.00
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TAR-T27091-50mg50mg£3,267.00
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Quantity:
TAR-T27091-100mg100mg£4,488.00
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This product comes from: United States.
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Further Information

Bioactivity:
Cryptopleurine is an inhibitor of gene products associated with cell proliferation, survival, invasion and angiogenesis. It acts by targeting the NF-κB pathway.
CAS:
482-22-4
Formula:
C24H27NO3
Molecular Weight:
377.484
Purity:
0.98
SMILES:
[H][C@]12CCCCN1Cc1c(C2)c2cc(OC)c(OC)cc2c2cc(OC)ccc12

References

1. Akter KM, Kim HJ, Khalil AAK, Park WS, Lee MK, Park JH, Ahn MJ. Inner morphological and chemical differentiation of Boehmeria species. J Nat Med. 2017 Dec 19. doi: 10.1007/s11418-017-1164-8. [Epub ahead of print] PubMed PMID: 29260412. 2. Wang Y, Lee S, Ha Y, Lam W, Chen SR, Dutschman GE, Gullen EA, Grill SP, Cheng Y, F?rstner A, Francis S, Baker DC, Yang X, Lee KH, Cheng YC. Tylophorine Analogs Allosterically Regulates Heat Shock Cognate Protein 70 And Inhibits Hepatitis C Virus Replication. Sci Rep. 2017 Aug 30;7(1):10037. doi: 10.1038/s41598-017-08815-z. PubMed PMID: 28855547; PubMed Central PMCID: PMC5577180. 3. Kwon Y, Song J, Lee H, Kim EY, Lee K, Lee SK, Kim S. Design, Synthesis, and Biological Activity of Sulfonamide Analogues of Antofine and Cryptopleurine as Potent and Orally Active Antitumor Agents. J Med Chem. 2015 Oct 8;58(19):7749-62. doi: 10.1021/acs.jmedchem.5b00764. Epub 2015 Sep 30. PubMed PMID: 26393416. 4. Chao MW, Wang LT, Lai CY, Yang XM, Cheng YW, Lee KH, Pan SL, Teng CM. eIF4E binding protein 1 expression is associated with clinical survival outcomes in colorectal cancer. Oncotarget. 2015 Sep 15;6(27):24092-104. PubMed PMID: 26204490; PubMed Central PMCID: PMC4695172.