TargetMol

DA-6886

Product Code:
 
TAR-T27117
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27117-1mg1mg£183.00
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TAR-T27117-5mg5mg£344.00
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TAR-T27117-10mg10mg£480.00
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TAR-T27117-25mg25mg£736.00
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TAR-T27117-50mg50mg£994.00
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TAR-T27117-100mg100mg£1,315.00
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Quantity:
TAR-T27117-500mg500mg£2,456.00
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Further Information

Bioactivity:
DA-6886 is an agonist 5-Hydroxytryptamine receptor 4 (5-HT4). DA-6886 induced relaxation of the rat oesophagus preparation in a 5-HT4 receptor antagonist-sensitive manner. The evaluation of DA-6886 in CHO cells expressing hERG channels revealed that it inhibited hERG channel current with an pIC50 value of 4.3, indicating that the compound was 1000-fold more selective for the 5-HT4 receptor over hERG channels.
CAS:
1645260-76-9
Formula:
C19H28Cl2N6O2
Molecular Weight:
443.37
Pathway:
GPCR/G Protein|Neuroscience
Purity:
0.98
SMILES:
Cl.COc1cc(N)c(Cl)cc1C(=O)NCC1CCN(CCCn2ccnn2)CC1
Target:
5-HT Receptor

References

1. Lee MJ, Cho KH, Park HM, Sung HJ, Choi S, Im W. Pharmacological profile of DA-6886, a novel 5-HT4 receptor agonist to accelerate colonic motor activity in mice. Eur J Pharmacol. 2014 Jul 15;735:115-22. doi: 10.1016/j.ejphar.2014.03.061. PubMed PMID: 24769304.