TargetMol

Dexamethasone cipecilate

Product Code:
 
TAR-T27153
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T27153-5mg5mgEnquire
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Further Information

Bioactivity:
Dexamethasone cipecilate is a long-acting intranasal corticosteroid and a highly lipophilic anti-inflammatory corticosteroid.
CAS:
132245-57-9
Formula:
C33H43FO7
Molecular Weight:
570.698
Purity:
0.98
SMILES:
[H][C@@]12C[C@@H](C)[C@](OC(=O)C3CC3)(C(=O)COC(=O)C3CCCCC3)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])CCC2=CC(=O)C=C[C@]12C

References

1. Sasagawa T, Yamada T, Nakagawa T, Tsujioka T, Takahashi Y, Kawakita N, Nonaka K, Nakamura A. In vitro metabolism of dexamethasone cipecilate, a novel synthetic corticosteroid, in human liver and nasal mucosa. Xenobiotica. 2011 Oct;41(10):874-84. doi: 10.3109/00498254.2011.582894. Epub 2011 Jun 10. PubMed PMID: 21657966. 2. Yu SQ, Wang DH. Enhanced salt sensitivity following shRNA silencing of neuronal TRPV1 in rat spinal cord. Acta Pharmacol Sin. 2011 Jun;32(6):845-52. doi: 10.1038/aps.2011.43. PubMed PMID: 21642952; PubMed Central PMCID: PMC4009958. 3. Gotoh M, Okubo K, Okuda M, Hamada C. Clinical pharmacology study of the corticosteroid nasal spray dexamethasone cipecilate (NS-126): examination of the durability of efficacy in the nasal induction test. Expert Opin Investig Drugs. 2010 Dec;19(12):1475-86. doi: 10.1517/13543784.2010.531258. Epub 2010 Nov 11. PubMed PMID: 21067470. 4. Inoue N, Hashino A, Kageyama K, Zhang X, Sasagawa T, Kawakita N, Takahashi Y, Yoshida K, Hashimoto M, Mori K, Kyoi T. Pharmacological profile of the novel anti-inflammatory corticosteroid NS-126, a therapeutic agent for allergic rhinitis. J Pharmacol Sci. 2010;112(1):73-82. Epub 2010 Jan 6. PubMed PMID: 20051657.