TargetMol

Emivirine

Product Code:
 
TAR-T27260
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27260-1mg1mg£111.00
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TAR-T27260-5mg5mg£168.00
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TAR-T27260-1mL1 mL * 10 mM (in DMSO)£177.00
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TAR-T27260-10mg10mg£229.00
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TAR-T27260-25mg25mg£348.00
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TAR-T27260-50mg50mg£485.00
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This product comes from: United States.
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Further Information

Bioactivity:
Emivirine is a potent and selective nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1.
CAS:
149950-60-7
Formula:
C17H22N2O3
Molecular Weight:
302.374
Pathway:
Microbiology/Virology|Proteases/Proteasome
Purity:
0.98
SMILES:
CCOCn1c(Cc2ccccc2)c(C(C)C)c(=O)[nH]c1=O
Target:
HIV Protease

References

1. El-Brollosy NR, Loddo R. Synthesis and Antiviral Evaluation of 1-[(2-Phenoxyethyl)oxymethyl] and 6-(3,5-Dimethoxybenzyl) Analogues of HIV Drugs Emivirine and TNK-651. Drug Res (Stuttg). 2016 Apr;66(4):181-8. doi: 10.1055/s-0035-1559683. Epub 2015 Aug 27. PubMed PMID: 26313923. 2. El-Brollosy NR, S?rensen ER, Pedersen EB, Sanna G, La Colla P, Loddo R. Synthesis and antiviral evaluation of 6-(trifluoromethylbenzyl) and 6-(fluorobenzyl) analogues of HIV drugs emivirine and GCA-186. Arch Pharm (Weinheim). 2008 Jan;341(1):9-19. PubMed PMID: 18161905. 3. Boudet N, Knochel P. Chemo- and regioselective functionalization of uracil derivatives. Applications to the synthesis of oxypurinol and emivirine. Org Lett. 2006 Aug 17;8(17):3737-40. PubMed PMID: 16898805. 4. Petersen L, J?rgensen PT, Nielsen C, Hansen TH, Nielsen J, Pedersen EB. Synthesis and evaluation of double-prodrugs against HIV. Conjugation of D4T with 6-benzyl-1-(ethoxymethyl)-5-isopropyluracil (MKC-442, emivirine)-type reverse transcriptase inhibitors via the SATE prodrug approach. J Med Chem. 2005 Feb 24;48(4):1211-20. PubMed PMID: 15715487.