TargetMol

FK-739 free acid

Product Code:
 
TAR-T27325
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27325-5mg5mg£850.00
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TAR-T27325-50mg50mg£1,661.00
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Quantity:
TAR-T27325-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
FK-739 is an angiotensin type 1 receptor antagonist. FK 739 inhibits the specific binding of [125I]-angiotensin II to rat aortic smooth muscle cell membrane (IC50 = 8.6 nM) without displacing the specific binding of [125I]-angiotensin II to bovine cerebellum membrane.
CAS:
133052-30-9
Formula:
C24H23N7
Molecular Weight:
409.497
Purity:
0.98
SMILES:
CCCCc1nc2cccnc2n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1

References

1. Kubo M, Umemoto S, Fujii K, Itoh S, Tanaka M, Kawahara S, Matsuzaki M. Effects of angiotensin II type 1 receptor antagonist on smooth muscle cell phenotype in intramyocardial arteries from spontaneously hypertensive rats. Hypertens Res. 2004 Sep;27(9):685-93. PubMed PMID: 15750263. 2. Yonezawa T, Umemoto S, Fujii A, Katayama K, Matsuzaki M. Comparative effects of type 1 angiotensin II-receptor blockade with angiotensin-converting-enzyme inhibitor on left ventricular distensibility and collagen metabolism in spontaneously hypertensive rats. J Cardiovasc Pharmacol. 1996 Jan;27(1):119-24. PubMed PMID: 8656644. 3. Itazaki K, Hara M, Itoh N, Fujimoto M. A long-term receptor stimulation is requisite for angiotensin II-dependent DNA synthesis in vascular smooth muscle cells from spontaneously hypertensive rats. Eur J Pharmacol. 1995 Nov 30;291(3):417-25. PubMed PMID: 8719428. 4. Bauer JH, Reams GP. The angiotensin II type 1 receptor antagonists. A new class of antihypertensive drugs. Arch Intern Med. 1995 Jul 10;155(13):1361-8. Review. PubMed PMID: 7794084.