TargetMol

Fluparoxan HCl

Product Code:
 
TAR-T27340
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27340-5mg5mg£850.00
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TAR-T27340-50mg50mg£1,661.00
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TAR-T27340-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
Fluparoxan is a potent α2-adrenergic receptor antagonist (pKB = 7.9) with excellent α2/α1 selectivity (2630 fold).
CAS:
105226-30-0
Formula:
C10H11ClFNO2
Molecular Weight:
231.65
Purity:
0.98
SMILES:
Cl.[H][C@]12CNC[C@]1([H])Oc1c(F)cccc1O2

References

1. Borthwick AD. Fluparoxan: A Comprehensive Review of its Discovery, Adrenergic and CNS activity and treatment of Cognitive Dysfunction in central Neurodegenerative diseases. Mini Rev Med Chem. 2016 Mar 21. [Epub ahead of print] PubMed PMID: 26996616. 2. Chu X, ?gmo A. The adrenergic ?2-receptor, sexual incentive motivation and copulatory behavior in the male rat. Pharmacol Biochem Behav. 2016 May;144:33-44. doi: 10.1016/j.pbb.2016.02.008. Epub 2016 Feb 22. PubMed PMID: 26906229. 3. Scullion GA, Kendall DA, Marsden CA, Sunter D, Pardon MC. Chronic treatment with the ?2-adrenoceptor antagonist fluparoxan prevents age-related deficits in spatial working memory in APP?PS1 transgenic mice without altering ?-amyloid plaque load or astrocytosis. Neuropharmacology. 2011 Feb-Mar;60(2-3):223-34. doi: 10.1016/j.neuropharm.2010.09.002. Epub 2010 Sep 17. PubMed PMID: 20850464. 4. Pauwels PJ, Tardif S, Wurch T, Colpaert FC. Facilitation of constitutive alpha(2A)-adrenoceptor activity by both single amino acid mutation (Thr(373)Lys) and g(alphao) protein coexpression: evidence for inverse agonism. J Pharmacol Exp Ther. 2000 Feb;292(2):654-63. PubMed PMID: 10640303.