TargetMol

Fonsartan free acid

Product Code:
 
TAR-T27347
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27347-5mg5mg£1,251.00
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TAR-T27347-50mg50mg£2,464.00
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Quantity:
TAR-T27347-100mg100mg£3,283.00
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This product comes from: United States.
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Further Information

Bioactivity:
Fonsartan is an angiotensin receptor antagonist. Fonsartan inhibits the angiotensin II-induced trophic effects, fibronectin release and fibronectin-EIIIA+ expression in rat aortic vascular smooth muscle cells in vitro.
CAS:
144628-52-4
Formula:
C26H32N4O5S2
Molecular Weight:
544.69
Purity:
0.98
SMILES:
CCCCc1nc(SC)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)NCCC

References

1. Hropot M, Langer KH, Wiemer G, Gr?tsch H, Linz W. Angiotensin II subtype AT1 receptor blockade prevents hypertension and renal insufficiency induced by chronic NO-synthase inhibition in rats. Naunyn Schmiedebergs Arch Pharmacol. 2003 Mar;367(3):312-7. PubMed PMID: 12644905. 2. Braun C, Kleemann T, Hilgenfeldt U, Riester U, Rohmeiss P, van der Woude FJ. Activity and functional significance of the renal kallikrein-kinin-system in polycystic kidney disease of the rat. Kidney Int. 2002 Jun;61(6):2149-56. PubMed PMID: 12028455. 3. Wassmann S, Laufs U, B?umer AT, M?ller K, Ahlbory K, Linz W, Itter G, R?sen R, B?hm M, Nickenig G. HMG-CoA reductase inhibitors improve endothelial dysfunction in normocholesterolemic hypertension via reduced production of reactive oxygen species. Hypertension. 2001 Jun;37(6):1450-7. PubMed PMID: 11408394. 4. Xia QG, Chung O, Spitznagel H, Illner S, J?nichen G, Rossius B, Gohlke P, Unger T. Significance of timing of angiotensin AT1 receptor blockade in rats with myocardial infarction-induced heart failure. Cardiovasc Res. 2001 Jan;49(1):110-7. PubMed PMID: 11121802.