TargetMol

FR 110302

Product Code:
 
TAR-T27359
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27359-5mg5mg£850.00
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TAR-T27359-50mg50mg£1,661.00
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Quantity:
TAR-T27359-100mg100mg£2,079.00
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  • Further Information
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Further Information

Bioactivity:
FR 110302 is a potent inhibitor of 5-lipoxygenase.
CAS:
119256-94-9
Formula:
C28H35NO2
Molecular Weight:
417.593
Purity:
0.98
SMILES:
CCCCC1(CCCC)CCc2c(OCc3ccc4ccccc4n3)cccc2[C@H]1O

References

1. Yatabe T, Kayakiri H, Kawai Y, Oku T, Tanaka H. Studies on 5-lipoxygenase inhibitors. II. Discovery, optical resolution and enantioselective synthesis of FR110302, a highly potent non-redox type 5-lipoxygenase inhibitor. Chem Pharm Bull (Tokyo). 1998 Oct;46(10):1556-65. PubMed PMID: 9810693. 2. Negro JM, Miralles JC, Ortiz JL, Funes E, Garc?a A. Biosynthesis inhibitors for leukotrienes in bronchial asthma. Allergol Immunopathol (Madr). 1997 Jul-Aug;25(4):209-16. Review. PubMed PMID: 9269512. 3. Asano M, Imai T, Inoue H, Masunaga T, Inamura N, Yatabe T, Hiroi J, Nakahara K, Notsu Y, Takishima T. A 5-lipoxygenase inhibitor, FR110302, inhibits ozone-induced airway hyperresponsiveness in guinea pigs and dogs. Agents Actions. 1993 Mar;38(3-4):171-7. PubMed PMID: 8213343. 4. Asano M, Inamura N, Nakahara K, Nagayoshi A, Isono T, Hamada K, Oku T, Notsu Y, Kohsaka M, Ono T. A 5-lipoxygenase inhibitor, FR110302, suppresses airway hyperresponsiveness and lung eosinophilia induced by Sephadex particles in rats. Agents Actions. 1992 Jul;36(3-4):215-21. PubMed PMID: 1382375.