TargetMol

FR-186054

Product Code:
 
TAR-T27376
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27376-5mg5mg£1,171.00
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TAR-T27376-50mg50mg£2,303.00
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Quantity:
TAR-T27376-100mg100mg£3,042.00
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Further Information

Bioactivity:
FR-186054 is a new, potent inhibitor of acyl-CoA:cholesterol O-acyltransferase (ACAT) and has oral activity. Compared to other ACAT inhibitors, this compound displayed excellent in vitro efficacy, irrespective of dosing method, indicating superior characteristics.
CAS:
179053-90-8
Formula:
C26H27N5OS2
Molecular Weight:
489.66
Purity:
0.98
SMILES:
CSc1cc(C)nc(SC)c1NC(=O)N(Cc1ccccc1)Cc1cccc(c1)-c1cc[nH]n1

References

1. Tanaka A, Terasawa T, Hagihara H, Kinoshita T, Sakuma Y, Ishibe N, Sawada M, Takasugi H, Tanaka H. Synthesis, X-ray crystal structure, and biological activity of FR186054, a novel, potent, orally active inhibitor of acyl-CoA:cholesterol O-acyltransferase (ACAT) bearing a pyrazole ring. Bioorg Med Chem Lett. 1998 Jan 6;8(1):81-6. PubMed PMID: 9871633. 2. Tanaka A, Terasawa T, Hagihara H, Sakuma Y, Ishibe N, Sawada M, Takasugi H, Tanaka H. Inhibitors of acyl-CoA:cholesterol O-acyltransferase. 2. Identification and structure-activity relationships of a novel series of N-alkyl-N-(heteroaryl-substituted benzyl)-N'-arylureas. J Med Chem. 1998 Jun 18;41(13):2390-410. PubMed PMID: 9632372.