TargetMol

Gacyclidine

Product Code:
 
TAR-T27397
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27397-1mg1mg£139.00
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TAR-T27397-5mg5mg£239.00
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TAR-T27397-10mg10mg£319.00
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TAR-T27397-25mg25mg£541.00
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TAR-T27397-50mg50mg£697.00
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TAR-T27397-100mg100mg£946.00
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TAR-T27397-500mg500mg£1,821.00
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This product comes from: United States.
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Further Information

Bioactivity:
Gacyclidine is a N-methyl-D-aspartate (NMDA) receptor antagonist. Local administration of gacyclidine to the cochlea can suppress salicylate-induced tinnitus.
CAS:
68134-81-6
Formula:
C16H25NS
Molecular Weight:
263.44
Pathway:
Neuroscience
Purity:
0.98
SMILES:
C[C@H]1CCCC[C@@]1(N1CCCCC1)c1cccs1
Target:
NMDAR

References

1. Chenoweth JA, Gerona RR, Ford JB, Sutter ME, Rose JS, Albertson TE, Clarke SO, Owen KP. Altered mental status and end organ damage associated with the use of gacyclidine: a case series. J Med Toxicol. 2015 Mar;11(1):115-20. doi: 10.1007/s13181-014-0415-2. PubMed PMID: 25048606; PubMed Central PMCID: PMC4371039. 2. Wenzel GI, Warnecke A, St?ver T, Lenarz T. Effects of extracochlear gacyclidine perfusion on tinnitus in humans: a case series. Eur Arch Otorhinolaryngol. 2010 May;267(5):691-9. doi: 10.1007/s00405-009-1126-1. PubMed PMID: 19847455. 3. Gerber YN, Privat A, Perrin FE. Gacyclidine improves the survival and reduces motor deficits in a mouse model of amyotrophic lateral sclerosis. Front Cell Neurosci. 2013 Dec 27;7:280. doi: 10.3389/fncel.2013.00280. PubMed PMID: 24409117; PubMed Central PMCID: PMC3873512. 4. Hoizey G, Kaltenbach ML, Dukic S, Lamiable D, Millart H, D'Arbigny P, Vistelle R. Pharmacokinetics of gacyclidine enantiomers in plasma and spinal cord after single enantiomer administration in rats. Int J Pharm. 2001 Oct 23;229(1-2):147-53. PubMed PMID: 11604267.