TargetMol

GL-331

Product Code:
 
TAR-T27414
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27414-5mg5mg£850.00
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Quantity:
TAR-T27414-50mg50mg£1,661.00
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Quantity:
TAR-T27414-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
GL-331, a DNA topoisomerase II inhibitor, is used potentially for the treatment of small cell lung cancer and gastric cancer.
CAS:
127882-73-9
Formula:
C27H24N2O9
Molecular Weight:
520.494
Purity:
0.98
SMILES:
[H][C@]12COC(=O)[C@]1([H])[C@H](c1cc(OC)c(O)c(OC)c1)c1cc3OCOc3cc1[C@H]2Nc1ccc(cc1)[N+]([O-])=O

References

1. Wang YJ, Chen XG, Xiao ZY, Liu GT, Sun H. Induction of cell cycle arrest by GL331 via triggering an ATM-dependent DNA damage response in HepG2 cells. J Asian Nat Prod Res. 2012;14(7):657-64. doi: 10.1080/10286020.2012.684683. Epub 2012 May 15. PubMed PMID: 22583615. 2. Lee CC, Huang TS. A novel topoisomerase II poison GL331 preferentially induces DNA cleavage at (C/G)T sites and can cause telomere DNA damage. Pharm Res. 2001 Jun;18(6):846-51. PubMed PMID: 11474790. 3. Huang TS, Lee CC, Chao Y, Shu CH, Chen LT, Chen LL, Chen MH, Yuan CC, Whang-Peng J. A novel podophyllotoxin-derived compound GL331 is more potent than its congener VP-16 in killing refractory cancer cells. Pharm Res. 1999 Jul;16(7):997-1002. PubMed PMID: 10450922. 4. Chen Y, Su YH, Wang CH, Wu JM, Chen JC, Tseng SH. Induction of apoptosis and cell cycle arrest in glioma cells by GL331 (a topoisomerase II inhibitor). Anticancer Res. 2005 Nov-Dec;25(6B):4203-8. PubMed PMID: 16309217.