TargetMol

Gue1654

Product Code:
 
TAR-T27502
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
❮❯

No additional charges, what you see is what you pay! *

CodeSizePrice
TAR-T27502-5mg5mg£850.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T27502-50mg50mg£1,661.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T27502-100mg100mg£2,079.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
Prices exclude any Taxes / VAT
How to order with us   Contact us
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: United States.
Typical lead time: 10-14 working days.
Contact us for more accurate information.
  • Further Information
  • Documents
  • References
  • Show All

Further Information

Bioactivity:
Gue1654 is a modulator of oxoeicosanoid receptor 1 (OXE-R). Gue1654 selectively inhibits Gβγ upon activation of the Gαi-βγ heterotrimer by OXE-R. Gue1654 inhibits Gβγ-mediated opening of GIRK1/2 channels in HEK293 cells.
CAS:
397290-30-1
Formula:
C23H17N3OS3
Molecular Weight:
447.59
Purity:
0.98
SMILES:
CSc1nc2ccc3nc(NC(=O)C(c4ccccc4)c4ccccc4)sc3c2s1

References

1. Cossette C, Gravel S, Reddy CN, Gore V, Chourey S, Ye Q, Snyder NW, Mesaros CA, Blair IA, Lavoie JP, Reinero CR, Rokach J, Powell WS. Biosynthesis and actions of 5-oxoeicosatetraenoic acid (5-oxo-ETE) on feline granulocytes. Biochem Pharmacol. 2015 Aug 1;96(3):247-55. doi: 10.1016/j.bcp.2015.05.009. PubMed PMID: 26032638; PubMed Central PMCID: PMC4830392. 2. Konya V, Bl?ttermann S, Jandl K, Platzer W, Ottersbach PA, Marsche G, G?tschow M, Kostenis E, Heinemann A. A biased non-G?i OXE-R antagonist demonstrates that G?i protein subunit is not directly involved in neutrophil, eosinophil, and monocyte activation by 5-oxo-ETE. J Immunol. 2014 May 15;192(10):4774-82. doi: 10.4049/jimmunol.1302013. PubMed PMID: 24733850. 3. Bl?ttermann S, Peters L, Ottersbach PA, Bock A, Konya V, Weaver CD, Gonzalez A, Schr?der R, Tyagi R, Luschnig P, G?b J, Hennen S, Ulven T, Pardo L, Mohr K, G?tschow M, Heinemann A, Kostenis E. A biased ligand for OXE-R uncouples G? and G?? signaling within a heterotrimer. Nat Chem Biol. 2012 Jul;8(7):631-8. doi: 10.1038/nchembio.962. PubMed PMID: 22634634.