TargetMol

GV-196771

Product Code:
 
TAR-T27504
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27504-5mg5mg£850.00
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TAR-T27504-50mg50mg£1,661.00
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TAR-T27504-100mg100mg£2,079.00
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Further Information

Bioactivity:
GV-196771 selectively antagonize the glycine-binding site of the NMDA ionophore.
CAS:
166974-22-7
Formula:
C20H14Cl2N2O3
Molecular Weight:
401.24
Purity:
0.98
SMILES:
OC(=O)c1[nH]c2cc(Cl)cc(Cl)c2c1C=C1/CCN(C1=O)c1ccccc1

References

1. Polli JW, Baughman TM, Humphreys JE, Jordan KH, Mote AL, Webster LO, Barnaby RJ, Vitulli G, Bertolotti L, Read KD, Serabjit-Singh CJ. The systemic exposure of an N-methyl-D-aspartate receptor antagonist is limited in mice by the P-glycoprotein and breast cancer resistance protein efflux transporters. Drug Metab Dispos. 2004 Jul;32(7):722-6. PubMed PMID: 15205387. 2. Wallace MS, Rowbotham MC, Katz NP, Dworkin RH, Dotson RM, Galer BS, Rauck RL, Backonja MM, Quessy SN, Meisner PD. A randomized, double-blind, placebo-controlled trial of a glycine antagonist in neuropathic pain. Neurology. 2002 Dec 10;59(11):1694-700. PubMed PMID: 12473754. 3. Iavarone L, Hoke JF, Bottacini M, Barnaby R, Preston GC. First time in human for GV196771: interspecies scaling applied on dose selection. J Clin Pharmacol. 1999 Jun;39(6):560-6. PubMed PMID: 10354959.