TargetMol

GW409544

Product Code:
 
TAR-T27508
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27508-5mg5mg£850.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T27508-50mg50mg£1,661.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T27508-100mg100mg£2,079.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
GW409544 is an agonist of PPAR-alpha and PPAR-gamma.
CAS:
258345-41-4
Formula:
C31H30N2O5
Molecular Weight:
510.59
Purity:
0.98
SMILES:
CC(N[C@@H](Cc1ccc(OCCc2nc(oc2C)-c2ccccc2)cc1)C(O)=O)=CC(=O)c1ccccc1

References

1. De Filippis B, Linciano P, Ammazzalorso A, Di Giovanni C, Fantacuzzi M, Giampietro L, Laghezza A, Maccallini C, Tortorella P, Lavecchia A, Loiodice F, Amoroso R. Structural development studies of PPARs ligands based on tyrosine scaffold. Eur J Med Chem. 2015 Jan 7;89:817-25. doi: 10.1016/j.ejmech.2014.10.083. PubMed PMID: 25462281. 2. Bravo Y, Baccei CS, Broadhead A, Bundey R, Chen A, Clark R, Correa L, Jacintho JD, Lorrain DS, Messmer D, Stebbins K, Prasit P, Stock N. Identification of the first potent, selective and bioavailable PPAR? antagonist. Bioorg Med Chem Lett. 2014 May 15;24(10):2267-72. doi: 10.1016/j.bmcl.2014.03.090. PubMed PMID: 24745969. 3. Moreno-Santos I, Pav?n FJ, Romero-Cuevas M, Serrano A, Cano C, Suard?az M, Decara J, Suarez J, de Fonseca FR, Mac?as-Gonz?lez M. Computational and biological evaluation of N-octadecyl-N'-propylsulfamide, a selective PPAR? agonist structurally related to N-acylethanolamines. PLoS One. 2014 Mar 20;9(3):e92195. doi: 10.1371/journal.pone.0092195. PubMed PMID: 24651609; PubMed Central PMCID: PMC3961330. 4. Decara JM, Romero-Cuevas M, Rivera P, Macias-Gonz?lez M, Vida M, Pav?n FJ, Serrano A, Cano C, Fresno N, P?rez-Fern?ndez R, Rodr?guez de Fonseca F, Su?rez J. Elaidyl-sulfamide, an oleoylethanolamide-modelled PPAR? agonist, reduces body weight gain and plasma cholesterol in rats. Dis Model Mech. 2012 Sep;5(5):660-70. doi: 10.1242/dmm.009233. PubMed PMID: 22736460; PubMed Central PMCID: PMC3424463.