Hirugen

Product Code:

TAR-T27545

Product Group:

Inhibitors and Activators

Supplier:

TargetMol

Regulatory Status:

RUO

Shipping:

cool pack

Storage:

-20℃

No additional charges, what you see is what you pay! *

Code	Size	Price

TAR-T27545-5mg

5mg

£850.00

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Quantity:

Prices exclude any Taxes / VAT

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Further Information

Bioactivity:

Hirugen is a derivative of hirudin, which is an anticoagulant protein found in leeches.

CAS:

121822-23-9

Formula:

C65H91N13O28S

Molecular Weight:

1534.57

Purity:

0.98

SMILES:

CC[C@H](C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccc(OS(O)(=O)=O)cc1)C(=O)N[C@@H](CC(C)C)C(O)=O

Documents

References

1. Glusa E. Desulfated hirugen (hirudin 54-65) induces endothelium-dependent relaxation of porcine pulmonary arteries. Thromb Haemost. 1994 Aug;72(2):318-21. PubMed PMID: 7530386. 2. Koh CY, Kumar S, Kazimirova M, Nuttall PA, Radhakrishnan UP, Kim S, Jagadeeswaran P, Imamura T, Mizuguchi J, Iwanaga S, Swaminathan K, Kini RM. Crystal structure of thrombin in complex with S-variegin: insights of a novel mechanism of inhibition and design of tunable thrombin inhibitors. PLoS One. 2011;6(10):e26367. doi: 10.1371/journal.pone.0026367. Epub 2011 Oct 28. PubMed PMID: 22053189; PubMed Central PMCID: PMC3203879. 3. Zavyalova E, Kopylov A. Multiple inhibitory kinetics reveal an allosteric interplay among thrombin functional sites. Thromb Res. 2015 Jan;135(1):212-6. doi: 10.1016/j.thromres.2014.11.005. Epub 2014 Nov 15. PubMed PMID: 25467079. 4. Zarpellon A, Celikel R, Roberts JR, McClintock RA, Mendolicchio GL, Moore KL, Jing H, Varughese KI, Ruggeri ZM. Binding of alpha-thrombin to surface-anchored platelet glycoprotein Ib(alpha) sulfotyrosines through a two-site mechanism involving exosite I. Proc Natl Acad Sci U S A. 2011 May 24;108(21):8628-33. doi: 10.1073/pnas.1017042108. Epub 2011 May 9. PubMed PMID: 21555542; PubMed Central PMCID: PMC3102361.