TargetMol

HLI98C

Product Code:
 
TAR-T27546
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1

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CodeSizePrice
TAR-T27546-5mg5mg£850.00
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TAR-T27546-50mg50mg£1,661.00
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Quantity:
TAR-T27546-100mg100mg£2,079.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
HLI98C is a HDM2 ubiquitin ligase inhibitor with anti-tumor activity.
CAS:
317326-90-2
Formula:
C17H9ClN4O4
Molecular Weight:
368.73
Purity:
0.98
SMILES:
[O-][N+](=O)c1ccc2n(-c3cccc(Cl)c3)c3nc(=O)[nH]c(=O)c3cc2c1

References

1. Dou X, Li X, Tao L, Hu C, Zhang L, He Q, Yang B, Hu Y. Synthesis and biological evaluation of novel pyrimido[4,5-b]quinoline-2,4- dione derivatives as MDM2 ubiquitin ligase inhibitors. Med Chem. 2013 Jun 1;9(4):581-7. PubMed PMID: 22920093. 2. Yang Y, Ludwig RL, Jensen JP, Pierre SA, Medaglia MV, Davydov IV, Safiran YJ, Oberoi P, Kenten JH, Phillips AC, Weissman AM, Vousden KH. Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells. Cancer Cell. 2005 Jun;7(6):547-59. PubMed PMID: 15950904. 3. Huang L, Hu B, Ni J, Wu J, Jiang W, Chen C, Yang L, Zeng Y, Wan R, Hu G, Wang X. Transcriptional repression of SOCS3 mediated by IL-6/STAT3 signaling via DNMT1 promotes pancreatic cancer growth and metastasis. J Exp Clin Cancer Res. 2016 Feb 4;35:27. doi: 10.1186/s13046-016-0301-7. PubMed PMID: 26847351; PubMed Central PMCID: PMC4743194. 4. Chen H, Wu G, Gao S, Guo R, Zhao Z, Yuan H, Liu S, Wu J, Lu X, Yuan X, Yu Z, Zu X, Xie N, Yang N, Hu Z, Sun Q, Zhang W. Discovery of Potent Small-Molecule Inhibitors of Ubiquitin-Conjugating Enzyme UbcH5c from ?-Santonin Derivatives. J Med Chem. 2017 Aug 2. doi: 10.1021/acs.jmedchem.6b01829. [Epub ahead of print] PubMed PMID: 28696694.