TargetMol

ICI 204448

Product Code:
 
TAR-T27577
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27577-5mg5mg£1,010.00
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TAR-T27577-50mg50mg£1,982.00
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Quantity:
TAR-T27577-100mg100mg£2,560.00
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  • Further Information
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Further Information

Bioactivity:
ICI 204448 is a potent and peripherally selective κ-opioid agonist.
CAS:
125190-72-9
Formula:
C23H26Cl2N2O4
Molecular Weight:
465.37
Purity:
0.98
SMILES:
CN(C(CN1CCCC1)c1cccc(OCC(O)=O)c1)C(=O)Cc1ccc(Cl)c(Cl)c1

References

1. Caram-Salas NL, Reyes-Garc?a G, Bartoszyk GD, Araiza-Salda?a CI, Ambriz-Tututi M, Rocha-Gonz?lez HI, Arreola-Espino R, Cruz SL, Granados-Soto V. Subcutaneous, intrathecal and periaqueductal grey administration of asimadoline and ICI-204448 reduces tactile allodynia in the rat. Eur J Pharmacol. 2007 Nov 14;573(1-3):75-83. PubMed PMID: 17643411. 2. Rawls SM, Ding Z, Gray AM, Cowan A. Peripheral kappa-opioid agonist, ICI 204448, evokes hypothermia in cold-exposed rats. Pharmacology. 2005 May;74(2):79-83. PubMed PMID: 15687734. 3. Ke?ta H, Kayser V, Guilbaud G. Antinociceptive effect of a kappa-opioid receptor agonist that minimally crosses the blood-brain barrier (ICI 204448) in a rat model of mononeuropathy. Eur J Pharmacol. 1995 Apr 24;277(2-3):275-80. PubMed PMID: 7493620. 4. Shaw JS, Carroll JA, Alcock P, Main BG. ICI 204448: a kappa-opioid agonist with limited access to the CNS. Br J Pharmacol. 1989 Apr;96(4):986-92. PubMed PMID: 2568146; PubMed Central PMCID: PMC1854424.