TargetMol

Indisetron Dihydrochloride

Product Code:
 
TAR-T27607
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27607-5mg5mg£850.00
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TAR-T27607-50mg50mg£1,661.00
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Quantity:
TAR-T27607-100mg100mg£2,079.00
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Further Information

Bioactivity:
Indisetron Dihydrochloride is a 5-HT(3) and 5-HT(4) receptor antagonist. Indisetron reduces 2-methyl-5-serotonin (HT)-induced bradycardia.
CAS:
160472-97-9
Formula:
C17H25Cl2N5O
Molecular Weight:
386.32
Purity:
0.98
SMILES:
Cl.Cl.CN1CC2CC(CC(C1)N2C)NC(=O)c1n[nH]c2ccccc12

References

1. Tsukagoshi S; Tokyo Cooperative Oncology Group. [Introduction of novel anti-emetic agent, indisetron hydrochloride, developed recently in Japan]. Gan To Kagaku Ryoho. 2005 Apr;32(4):567-73. Review. Japanese. PubMed PMID: 15853230. 2. Iritani E, Isono K, Izumo T, Takeda N, Kanemura T, Tamaoki J, Nagai A. [The efficacy of indisetron hydrochloride for the management of chemotherapy-induced nausea and vomiting for lung cancer]. Gan To Kagaku Ryoho. 2009 Sep;36(9):1489-92. Japanese. PubMed PMID: 19755818. 3. Kanbe M, Osada M. [CPT-11-induced diarrhea treated with indisetron hydrochloride--a case report]. Gan To Kagaku Ryoho. 2005 Dec;32(13):2145-7. Japanese. PubMed PMID: 16352947. 4. Nakatsumi H, Komatsu Y, Yuki S, Sogabe S, Tateyama M, Muto S, Kudo M, Kato K, Miyagishima T, Uebayashi M, Meguro T, Oba K, Asaka M. Optimal dose period for indisetron tablets for preventing chemotherapy-induced nausea and vomiting with modified FOLFOX6: a randomized pilot study. Chemotherapy. 2012;58(6):439-44. doi: 10.1159/000345920. Epub 2013 Jan 29. PubMed PMID: 23364217.