TargetMol

IQP-0528

Product Code:
 
TAR-T27625
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27625-1mg1mg£177.00
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TAR-T27625-5mg5mg£328.00
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TAR-T27625-1mL1 mL * 10 mM (in DMSO)£334.00
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TAR-T27625-10mg10mg£456.00
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TAR-T27625-25mg25mg£702.00
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TAR-T27625-50mg50mg£938.00
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TAR-T27625-100mg100mg£1,259.00
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TAR-T27625-500mg500mg£2,448.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
IQP-0528, a non-nucleoside reverse transcriptase inhibitor, is used potentially for the treatment of HIV infection by blocking virus entry and has shown antiviral activity as microbicide gels.
CAS:
301297-45-0
Formula:
C20H24N2O3
Molecular Weight:
340.423
Pathway:
Microbiology/Virology|Proteases/Proteasome|Immunology/Inflammation
Purity:
0.98
SMILES:
CC(C)c1c(C(=O)c2cc(C)cc(C)c2)n(CC2CC2)c(=O)[nH]c1=O
Target:
HIV Protease|Reverse Transcriptase|Antiviral

References

1. Pereira LE, Mesquita PM, Ham A, Singletary T, Deyounks F, Martin A, McNicholl J, Buckheit KW, Buckheit RW Jr, Smith JM. Pharmacokinetic and Pharmacodynamic Evaluation following Vaginal Application of IQB3002, a Dual-Chamber Microbicide Gel Containing the Nonnucleoside Reverse Transcriptase Inhibitor IQP-0528 in Rhesus Macaques. Antimicrob Agents Chemother. 2015 Dec 14;60(3):1393-400. doi: 10.1128/AAC.02201-15. PubMed PMID: 26666935; PubMed Central PMCID: PMC4775942. 2. Srinivasan P, Zhang J, Martin A, Kelley K, McNicholl JM, Buckheit RW Jr, Smith JM, Ham AS. Safety and Pharmacokinetics of Quick-Dissolving Polymeric Vaginal Films Delivering the Antiretroviral IQP-0528 for Preexposure Prophylaxis. Antimicrob Agents Chemother. 2016 Jun 20;60(7):4140-50. doi: 10.1128/AAC.00082-16. PubMed PMID: 27139475; PubMed Central PMCID: PMC4914618. 3. Dezzutti CS, Shetler C, Mahalingam A, Ugaonkar SR, Gwozdz G, Buckheit KW, Buckheit RW Jr. Safety and efficacy of tenofovir/IQP-0528 combination gels - a dual compartment microbicide for HIV-1 prevention. Antiviral Res. 2012 Nov;96(2):221-5. doi: 10.1016/j.antiviral.2012.08.004. PubMed PMID: 22940075; PubMed Central PMCID: PMC3501576. 4. Ham AS, Rohan LC, Boczar A, Yang L, W Buckheit K, Buckheit RW Jr. Vaginal film drug delivery of the pyrimidinedione IQP-0528 for the prevention of HIV infection. Pharm Res. 2012 Jul;29(7):1897-907. doi: 10.1007/s11095-012-0715-7. PubMed PMID: 22392331; PubMed Central PMCID: PMC4405790.