TargetMol

Isbogrel

Product Code:
 
TAR-T27630
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27630-1mg1mg£352.00
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TAR-T27630-5mg5mg£736.00
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TAR-T27630-10mg10mg£978.00
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TAR-T27630-25mg25mg£1,348.00
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TAR-T27630-50mg50mg£1,661.00
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Quantity:
TAR-T27630-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
Isbogrel is a selective inhibitor of thromboxane A2 (TXA2) synthase.
CAS:
89667-40-3
Formula:
C18H19NO2
Molecular Weight:
281.355
Pathway:
GPCR/G Protein|Immunology/Inflammation
Purity:
0.98
SMILES:
OC(=O)CCCCC=C(/c1ccccc1)c1cccnc1
Target:
Prostaglandin Receptor

References

1. Miyatake T, Kubota S, Miyazaki K, Watanabe S, Mafune N, Murashita T, Yasuda K. Analysis of cardiac function during hyperacute rejection: effects of PAF antagonist, TXA(2) inhibitor/antagonists, and nitroglycerin. Transplant Proc. 2000 Aug;32(5):999-1000. PubMed PMID: 10936319. 2. Umetani K, Tamura K, Komori S, Watanabe A, Ishihara T, Mochizuki S, Li B, Ijiri H. Inhibitory effect of CV4151, a thromboxane A2 synthetase inhibitor, on ventricular arrhythmias induced by coronary artery occlusion in rats. Jpn Circ J. 1996 Jun;60(6):349-54. PubMed PMID: 8844301. 3. Terashita Z, Imura Y, Nishikawa K. Inhibition of arachidonic acid induced-aggregation of rabbit platelets with CV-4151 (isbogrel), a selective thromboxane A2 (TXA2) synthase inhibitor: modulation of the antiplatelet action and prostanoid metabolism by rat aortic rings. J Lipid Mediat Cell Signal. 1996 Jan;13(1):1-8. PubMed PMID: 8821806. 4. Hsu LY, Lee CF, Chou TC, Ding YA. 2-Heteroaryl 2-substituted phenylketone derivatives and their inhibitory activity on platelet aggregation. J Pharm Pharmacol. 1995 Sep;47(9):762-7. PubMed PMID: 8583390.