TargetMol

JN403

Product Code:
 
TAR-T27657
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27657-5mg5mg£850.00
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TAR-T27657-50mg50mg£1,661.00
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Quantity:
TAR-T27657-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
JN403 is a selective agonist of nicotinic acetylcholine receptor alpha7.
CAS:
942606-12-4
Formula:
C16H21FN2O2
Molecular Weight:
292.354
Purity:
0.98
SMILES:
Fc1ccccc1CCOC(=O)N[C@@H]1CN2CCC1CC2

References

1. Lilja AM, Malmsten L, R?jdner J, Voytenko L, Verkhratsky A, ?gren SO, Nordberg A, Marutle A. Neural Stem Cell Transplant-Induced Effect on Neurogenesis and Cognition in Alzheimer Tg2576 Mice Is Inhibited by Concomitant Treatment with Amyloid-Lowering or Cholinergic ?7 Nicotinic Receptor Drugs. Neural Plast. 2015;2015:370432. doi: 10.1155/2015/370432. Epub 2015 Jul 15. PubMed PMID: 26257960; PubMed Central PMCID: PMC4518185. 2. Arias HR, De Rosa MJ, Berg? I, Feuerbach D, Bouzat C. Differential pharmacological activity of JN403 between ?7 and muscle nicotinic acetylcholine receptors. Biochemistry. 2013 Nov 26;52(47):8480-8. doi: 10.1021/bi4012572. Epub 2013 Nov 11. PubMed PMID: 24164482. 3. Chen SG, Gu RX, Dai H, Wei DQ. Virtual screening for alpha7 nicotinic acetylcholine receptor for treatment of Alzheimer's disease. J Mol Graph Model. 2013 Feb;39:98-107. doi: 10.1016/j.jmgm.2012.11.008. Epub 2012 Nov 29. PubMed PMID: 23261879. 4. Ni R, Marutle A, Nordberg A. Modulation of ?7 nicotinic acetylcholine receptor and fibrillar amyloid-? interactions in Alzheimer's disease brain. J Alzheimers Dis. 2013;33(3):841-51. doi: 10.3233/JAD-2012-121447. PubMed PMID: 23042213.