TargetMol

K118

Product Code:
 
TAR-T27707
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27707-5mg5mg£850.00
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Quantity:
TAR-T27707-50mg50mg£1,661.00
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Quantity:
TAR-T27707-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
K118 is an inhibitor of SH2-containing inositol 5' phosphatase 1 (SHIP1). It reverses diet- and age-associated obesity and metabolic syndrome.
CAS:
54156-23-9
Formula:
C19H34ClN
Molecular Weight:
311.94
Purity:
0.98
SMILES:
Cl.C[C@@]12CCC[C@H]1[C@@H]1CC[C@H]3C[C@@H](N)CC[C@]3(C)[C@H]1CC2

References

1. Brooks R, Iyer S, Akada H, Neelam S, Russo CM, Chisholm JD, Kerr WG. Coordinate expansion of murine hematopoietic and mesenchymal stem cell compartments by SHIPi. Stem Cells. 2015 Mar;33(3):848-58. doi: 10.1002/stem.1902. PubMed PMID: 25402778. 2. Srivastava N, Iyer S, Sudan R, Youngs C, Engelman RW, Howard KT, Russo CM, Chisholm JD, Kerr WG. A small-molecule inhibitor of SHIP1 reverses age- and diet-associated obesity and metabolic syndrome. JCI Insight. 2016 Jul 21;1(11). pii: e88544. PubMed PMID: 27536730; PubMed Central PMCID: PMC4985248.