TargetMol

KBP-7018

Product Code:
 
TAR-T27715
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27715-5mg5mg£930.00
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Quantity:
TAR-T27715-50mg50mg£1,821.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T27715-100mg100mg£2,319.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
KBP-7018 is a potent, selective tyrosine kinase inhibitor with effects on three fibrotic kinases c-KIT, RET, and PDGFR (IC50 values are 10nM, 7.6 nM and 25nM respectively).
CAS:
1613437-66-3
Formula:
C31H30N4O5
Molecular Weight:
538.604
Purity:
0.98
SMILES:
COC(=O)c1ccc2C(=C(Nc3ccc4N(CCc4c3)C(=O)CN3CCOCC3)c3ccccc3)C(=O)Nc2c1

References

1. Discovery of Indolinone-Based Multikinase Inhibitors as Potential Therapeutics for Idiopathic Pulmonary Fibrosis Zhenhua Huang, Heran Li, Qian Zhang, Fangzheng Lu, Mei Hong, Zhigang Zhang, Xiaocui Guo, Yuanju Zhu, Sanming Li, and Hongzhuo Liu Publication Date (Web): September 30, 2017 (Letter) doi: 10.1021/acsmedchemlett.7b00164 2. Huang Z, Li H, Zhang Q, Tan X, Lu F, Liu H, Li S. Characterization of preclinical in vitro and in vivo pharmacokinetics properties for KBP-7018, a new tyrosine kinase inhibitor candidate for treatment of idiopathic pulmonary fibrosis. Drug Des Devel Ther. 2015 Aug 5;9:4319-28. doi: 10.2147/DDDT.S83055. eCollection 2015. PubMed PMID: 26273193; PubMed Central PMCID: PMC4532346.