TargetMol

KF24345

Product Code:
 
TAR-T27728
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1

No additional charges, what you see is what you pay! *

CodeSizePrice
TAR-T27728-5mg5mg£850.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T27728-50mg50mg£1,661.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T27728-100mg100mg£2,079.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
Prices exclude any Taxes / VAT
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: United States.
Typical lead time: 10-14 working days.
Contact us for more accurate information.
  • Further Information
  • Documents
  • References
  • Show All

Further Information

Bioactivity:
KF24345 is an inhibitor of adenosine uptake.
CAS:
178750-21-5
Formula:
C31H38N6O5
Molecular Weight:
574.682
Purity:
0.98
SMILES:
CCOc1cc2nc(nc(N3CCC(CC3)n3c(=O)n(C)c4ccc(C)cc4c3=O)c2cc1OCC)N1CCOCC1

References

1. Hammond JR, Archer RG. Interaction of the novel adenosine uptake inhibitor 3-[1-(6,7-diethoxy-2-morpholinoquinazolin-4-yl)piperidin-4-yl]-1,6-dimethyl-2,4(1 H,3H)-quinazolinedione hydrochloride (KF24345) with the es and ei subtypes of equilibrative nucleoside transporters. J Pharmacol Exp Ther. 2004 Mar;308(3):1083-93. PubMed PMID: 14634039. 2. Noji T, Karasawa A, Kusaka H. [Pharmacological study on the effects of the adenosine uptake inhibitor KF24345 on inflammatory diseases]. Nihon Yakurigaku Zasshi. 2003 Aug;122(2):121-34. Review. Japanese. PubMed PMID: 12890898. 3. Noji T, Nan-ya K, Mizutani M, Katagiri C, Sano J, Takada C, Nishikawa S, Karasawa A, Kusaka H. KF24345, an adenosine uptake inhibitor, ameliorates the severity and mortality of lethal acute pancreatitis via endogenous adenosine in mice. Eur J Pharmacol. 2002 Nov 1;454(1):85-93. PubMed PMID: 12409009. 4. Noji T, Takayama M, Mizutani M, Okamura Y, Takai H, Karasawa A, Kusaka H. KF24345, an adenosine uptake inhibitor, suppresses lipopolysaccharide-induced tumor necrosis factor-alpha production and leukopenia via endogenous adenosine in mice. J Pharmacol Exp Ther. 2002 Jan;300(1):200-5. PubMed PMID: 11752117.