TargetMol

KM-003 (sulfite)

Product Code:
 
TAR-T27734
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27734-5mg5mg£850.00
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Quantity:
TAR-T27734-50mg50mg£1,661.00
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Quantity:
TAR-T27734-100mg100mg£2,079.00
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This product comes from: United States.
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Further Information

Bioactivity:
KM-003, a sodium channel blocker, is used potentially for the treatment of cystic fibrosis.
CAS:
587879-54-7
Formula:
C20H30ClN7O7S
Molecular Weight:
548.01
Purity:
0.98
SMILES:
CS(O)(=O)=O.Nc1nc(N)c(nc1Cl)C(=O)NC=NNCCCCc1ccc(OCC(O)CO)cc1

References

1. Coote KJ, Paisley D, Czarnecki S, Tweed M, Watson H, Young A, Sugar R, Vyas M, Smith NJ, Baettig U, Groot-Kormelink PJ, Gosling M, Lock R, Ethell B, Williams G, Schumacher A, Harris J, Abraham WM, Sabater J, Poll CT, Faller T, Collingwood SP, Danahay H. NVP-QBE170: an inhaled blocker of the epithelial sodium channel with a reduced potential to induce hyperkalaemia. Br J Pharmacol. 2015 Jun;172(11):2814-26. doi: 10.1111/bph.13075. PubMed PMID: 25573195; PubMed Central PMCID: PMC4439877. 2. Enomoto G, Hirose Y, Narikawa R, Ikeuchi M. Thiol-based photocycle of the blue and teal light-sensing cyanobacteriochrome Tlr1999. Biochemistry. 2012 Apr 10;51(14):3050-8. doi: 10.1021/bi300020u. PubMed PMID: 22439675. 3. Paczkowski FA, Bryan-Lluka LJ. Role of proline residues in the expression and function of the human noradrenaline transporter. J Neurochem. 2004 Jan;88(1):203-11. PubMed PMID: 14675164. 4. Cheng Y, Slon-Usakiewicz JJ, Wang J, Purisima EO, Konishi Y. Nonpolar interactions of thrombin and its inhibitors at the fibrinogen recognition exosite: thermodynamic analysis. Biochemistry. 1996 Oct 8;35(40):13021-9. PubMed PMID: 8855937.