TargetMol

KRM-II-81

Product Code:
 
TAR-T27744
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
❮❯

No additional charges, what you see is what you pay! *

CodeSizePrice
TAR-T27744-5mg5mg£1,091.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T27744-50mg50mg£2,143.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T27744-100mg100mg£2,801.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
Prices exclude any Taxes / VAT
How to order with us   Contact us
Stay in control of your spending. These prices have no additional charges, not even shipping!
* Rare exceptions are clearly labelled (only 0.14% of items!).
Multibuy discounts available! Contact us to find what you can save.
This product comes from: United States.
Typical lead time: 10-14 working days.
Contact us for more accurate information.
  • Further Information
  • Documents
  • References
  • Show All

Further Information

Bioactivity:
KRM-II-81 is a γ?Aminobutyric Acid Type A (GABAA) Receptor Ligand. KRM-II-81 exhibits improved anxiolytic-like effects in a mouse marble burying assay and a rat Vogel conflict test.
CAS:
2014348-91-3
Formula:
C21H13N5O
Molecular Weight:
351.369
Purity:
0.98
SMILES:
C#Cc1ccc-2c(c1)C(=NCc1c(ncn-21)-c1cnco1)c1ccccn1

References

1. Synthesis and Characterization of a Novel ?-Aminobutyric Acid Type A (GABAA) Receptor Ligand That Combines Outstanding Metabolic Stability, Pharmacokinetics, and Anxiolytic Efficacy Michael M. Poe, Kashi Reddy Methuku, Guanguan Li, Ashwini R. Verma, Kelly A. Teske, Douglas C. Stafford, Leggy A. Arnold, Jeffrey W. Cramer, Timothy M. Jones, Rok Cerne, Michael J. Krambis, Jeffrey M. Witkin, Enrique Jambrina, Sabah Rehman, Margot Ernst, James M. Cook, and Jeffrey M. Schkeryantz Publication Date (Web): November 11, 2016 (Brief Article) doi: 10.1021/acs.jmedchem.6b01332