TargetMol

L-697639

Product Code:
 
TAR-T27769
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27769-5mg5mg£1,251.00
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TAR-T27769-50mg50mg£2,464.00
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Quantity:
TAR-T27769-100mg100mg£3,283.00
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This product comes from: United States.
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Further Information

Bioactivity:
L-697639 inhibits of HIV-1 reverse transcriptase and HIV-1 replication.
CAS:
135525-77-8
Formula:
C18H21N3O2
Molecular Weight:
311.385
Purity:
0.98
SMILES:
CCc1cc(NCc2nc3c(C)ccc(C)c3o2)c(=O)[nH]c1C

References

1. Sismour AM, Lutz S, Park JH, Lutz MJ, Boyer PL, Hughes SH, Benner SA. PCR amplification of DNA containing non-standard base pairs by variants of reverse transcriptase from Human Immunodeficiency Virus-1. Nucleic Acids Res. 2004 Feb 2;32(2):728-35. PubMed PMID: 14757837; PubMed Central PMCID: PMC373358. 2. Van Hecken A, Depre M, De Lepeleire I, Laskin O, Au T, Woolf E, Yeh KC, De Schepper PJ. Human pharmacokinetics and tolerability of L-697,639, a non-nucleoside HIV-1 reverse transcriptase inhibitor. Int J Clin Pharmacol Res. 1994;14(2):45-50. PubMed PMID: 7530697. 3. O'Brien JA, Ostovic D, Schorn TW, Smith SJ, Ruffing TL, Siegl PK, Goldman ME. A rapid bioassay for the determination of non-nucleoside HIV-1 reverse transcriptase inhibitor plasma levels. Life Sci. 1993;52(3):243-9. PubMed PMID: 7678687. 4. Saari WS, Wai JS, Fisher TE, Thomas CM, Hoffman JM, Rooney CS, Smith AM, Jones JH, Bamberger DL, Goldman ME, et al. Synthesis and evaluation of 2-pyridinone derivatives as HIV-1-specific reverse transcriptase inhibitors. 2. Analogues of 3-aminopyridin-2(1H)-one. J Med Chem. 1992 Oct 16;35(21):3792-802. PubMed PMID: 1279173.