TargetMol

LSP1-2111

Product Code:
 
TAR-T27856
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27856-5mg5mg£850.00
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TAR-T27856-50mg50mg£1,661.00
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Quantity:
TAR-T27856-100mg100mg£2,079.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
LSP1-2111 is a mGlu4 receptor subtype agonist.
CAS:
936234-43-4
Formula:
C12H17N2O9P
Molecular Weight:
364.247
Purity:
0.98
SMILES:
COc1cc(cc(c1O)[N+]([O-])=O)C(O)P(O)(=O)CC[C@H](N)C(O)=O

References

1. Cajina M, Nattini M, Song D, Smagin G, J?rgensen EB, Chandrasena G, Bundgaard C, Toft DB, Huang X, Acher F, Doller D. Qualification of LSP1-2111 as a Brain Penetrant Group III Metabotropic Glutamate Receptor Orthosteric Agonist. ACS Med Chem Lett. 2013 Dec 12;5(2):119-23. doi: 10.1021/ml400338f. PubMed PMID: 24900783; PubMed Central PMCID: PMC4027608. 2. Wiero?ska JM, Acher FC, S?awi?ska A, Gruca P, Laso?-Tyburkiewicz M, Papp M, Pilc A. The antipsychotic-like effects of the mGlu group III orthosteric agonist, LSP1-2111, involves 5-HT?A signalling. Psychopharmacology (Berl). 2013 Jun;227(4):711-25. doi: 10.1007/s00213-013-3005-0. PubMed PMID: 23474845; PubMed Central PMCID: PMC3663209. 3. Wiero?ska JM, Stachowicz K, Acher F, Lech T, Pilc A. Opposing efficacy of group III mGlu receptor activators, LSP1-2111 and AMN082, in animal models of positive symptoms of schizophrenia. Psychopharmacology (Berl). 2012 Apr;220(3):481-94. doi: 10.1007/s00213-011-2502-2. PubMed PMID: 21952670; PubMed Central PMCID: PMC3299972. 4. Wiero?ska JM, Stachowicz K, Pa?ucha-Poniewiera A, Acher F, Bra?ski P, Pilc A. Metabotropic glutamate receptor 4 novel agonist LSP1-2111 with anxiolytic, but not antidepressant-like activity, mediated by serotonergic and GABAergic systems. Neuropharmacology. 2010 Dec;59(7-8):627-34. doi: 10.1016/j.neuropharm.2010.08.008. PubMed PMID: 20713068.