TargetMol

LY255582

Product Code:
 
TAR-T27934
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T27934-5mg5mg£464.00
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TAR-T27934-50mg50mg£1,637.00
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Quantity:
TAR-T27934-100mg100mg£3,123.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
LY255582 is a phenylpiperidine non-selective opioid antagonist. LY255582 inhibits the diet-associated increases in mesolimbic dopamine levels and reduces the consumption of highly-palatable food intake.
CAS:
119193-09-8
Formula:
C22H35NO2
Molecular Weight:
345.527
Pathway:
Endocrinology/Hormones|Neuroscience|GPCR/G Protein
Purity:
0.98
SMILES:
C[C@H]1CN(CC[C@H](O)C2CCCCC2)CC[C@@]1(C)c1cccc(O)c1
Target:
Opioid Receptor

References

1. Ibrahim IY, Ibrahim HM, Aziz NM, Rahman DM. The protective role of the opioid antagonist LY255582 in the management of high fat diet-induced obesity in adult male albino rats. Endocr Regul. 2015 Oct;49(4):198-205. PubMed PMID: 26494038. 2. Dhaher R, Toalston JE, Hauser SR, Bell RL, McKinzie DL, McBride WJ, Rodd ZA. Effects of naltrexone and LY255582 on ethanol maintenance, seeking, and relapse responding by alcohol-preferring (P) rats. Alcohol. 2012 Feb;46(1):17-27. doi: 10.1016/j.alcohol.2011.08.011. Epub 2011 Oct 1. PubMed PMID: 21962974; PubMed Central PMCID: PMC4581853. 3. Shaw WN. Long-term treatment of obese Zucker rats with LY255582 and other appetite suppressants. Pharmacol Biochem Behav. 1993 Nov;46(3):653-9. PubMed PMID: 8278442. 4. Shaw WN, Mitch CH, Leander JD, Mendelsohn LG, Zimmerman DM. The effect of the opioid antagonist LY255582 on body weight of the obese Zucker rat. Int J Obes. 1991 Jun;15(6):387-95. PubMed PMID: 1653188.