TargetMol

LY382884

Product Code:
 
TAR-T27949
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1

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CodeSizePrice
TAR-T27949-5mg5mg£1,332.00
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Quantity:
TAR-T27949-50mg50mg£2,625.00
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Quantity:
TAR-T27949-100mg100mg£3,524.00
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This product comes from: United States.
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Further Information

Bioactivity:
LY382884 is a GLU(K5) receptor antagonist. LY382884 selectively binds the GLU(K5) kainate receptor subunit (K(b)=0.6 μM) and has 30 μM or greater affinity for cloned human AMPA receptor subtypes.
CAS:
211566-75-5
Formula:
C18H23NO4
Molecular Weight:
317.385
Purity:
0.98
SMILES:
[H][C@@]12CC[C@H](Cc3ccc(cc3)C(O)=O)C[C@]1([H])C[C@H](NC2)C(O)=O

References

1. Alt A, Weiss B, Ornstein PL, Gleason SD, Bleakman D, Stratford RE Jr, Witkin JM. Anxiolytic-like effects through a GLUK5 kainate receptor mechanism. Neuropharmacology. 2007 Jun;52(7):1482-7. Epub 2007 Mar 2. PubMed PMID: 17418283. 2. Binns KE, Turner JP, Salt TE. Kainate receptor (GluR5)-mediated disinhibition of responses in rat ventrobasal thalamus allows a novel sensory processing mechanism. J Physiol. 2003 Sep 1;551(Pt 2):525-37. Epub 2003 Aug 8. PubMed PMID: 12909680; PubMed Central PMCID: PMC2343236. 3. Evanson NK, Van Hooren DC, Herman JP. GluR5-mediated glutamate signaling regulates hypothalamo-pituitary-adrenocortical stress responses at the paraventricular nucleus and median eminence. Psychoneuroendocrinology. 2009 Oct;34(9):1370-9. doi: 10.1016/j.psyneuen.2009.04.011. Epub 2009 May 18. PubMed PMID: 19450932; PubMed Central PMCID: PMC2763572. 4. Palecek J, Neugebauer V, Carlton SM, Iyengar S, Willis WD. The effect of a kainate GluR5 receptor antagonist on responses of spinothalamic tract neurons in a model of peripheral neuropathy in primates. Pain. 2004 Sep;111(1-2):151-61. PubMed PMID: 15327819.