TargetMol

MEK Inhibitor I

Product Code:
 
TAR-T28012
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28012-1mg1mg£352.00
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TAR-T28012-5mg5mg£736.00
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TAR-T28012-25mg25mg£1,291.00
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TAR-T28012-50mg50mg£1,661.00
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This product comes from: United States.
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  • Further Information
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Further Information

Bioactivity:
MEK Inhibitor I is a selective and potent MEK inhibitor.
CAS:
297744-42-4
Formula:
C21H18N4OS
Molecular Weight:
374.46
Pathway:
MAPK
Purity:
0.98
SMILES:
NC(Sc1ccccc1N)=C(/C#N)c1cccc(c1)C(O)c1ccncc1
Target:
MEK

Documents

References

1. Johnson D. Is there a role for single-agent MEK inhibition in melanoma? Clin Adv Hematol Oncol. 2016 Dec;14(12):976-978. PubMed PMID: 28212360. 2. Thomas CL, Mortimer PS, Larkin JM, Basu TN, Gore ME, Fearfield L. A mitogen-activated protein kinase kinase inhibitor induced compound skin toxicity with oedema in metastatic malignant melanoma. Clin Exp Dermatol. 2016 Apr;41(3):267-71. doi: 10.1111/ced.12722. Epub 2015 Sep 28. PubMed PMID: 26411345. 3. Crassini K, Stevenson WS, Mulligan SP, Best OG. The MEK1/2 inhibitor, MEKi-1, induces cell death in chronic lymphocytic leukemia cells under conditions that mimic the tumor microenvironment and is synergistic with fludarabine. Leuk Lymphoma. 2015;56(12):3407-17. doi: 10.3109/10428194.2015.1032963. Epub 2015 Aug 26. PubMed PMID: 25804768. 4. Shen B, Kwan HY, Ma X, Wong CO, Du J, Huang Y, Yao X. cAMP activates TRPC6 channels via the phosphatidylinositol 3-kinase (PI3K)-protein kinase B (PKB)-mitogen-activated protein kinase kinase (MEK)-ERK1/2 signaling pathway. J Biol Chem. 2011 Jun 3;286(22):19439-45. doi: 10.1074/jbc.M110.210294. Epub 2011 Apr 12. PubMed PMID: 21487005; PubMed Central PMCID: PMC3103323.