TargetMol

Metesind

Product Code:
 
TAR-T28023
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28023-5mg5mg£1,010.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T28023-50mg50mg£1,982.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T28023-100mg100mg£2,560.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
Metesind, a thymidylate synthase inhibitor, is used potentially for the treatment of brain cancer and solid tumours.
CAS:
138384-68-6
Formula:
C23H24N4O3S
Molecular Weight:
436.53
Purity:
0.98
SMILES:
CN(Cc1ccc(cc1)S(=O)(=O)N1CCOCC1)c1ccc2N=C(N)c3cccc1c23

References

1. Bram E, Ifergan I, Shafran A, Berman B, Jansen G, Assaraf YG. Mutant Gly482 and Thr482 ABCG2 mediate high-level resistance to lipophilic antifolates. Cancer Chemother Pharmacol. 2006 Dec;58(6):826-34. PubMed PMID: 16612649. 2. Tsai WC, Wilke TL, Tyle P. Development and validation of an HPLC method for AG331 bulk drug substance and lyophilized powder for injection. J Pharm Biomed Anal. 2004 Jun 29;35(4):697-702. PubMed PMID: 15193714. 3. Wu Q, Dolnick BJ. Detection of thymidylate synthase modulators by a novel screening assay. Mol Pharmacol. 2003 Jan;63(1):167-73. PubMed PMID: 12488549. 4. Danenberg PV, Malli H, Swenson S. Thymidylate synthase inhibitors. Semin Oncol. 1999 Dec;26(6):621-31. Review. PubMed PMID: 10606255.