TargetMol

Milfasartan

Product Code:
 
TAR-T28039
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28039-5mg5mg£850.00
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TAR-T28039-50mg50mg£1,661.00
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TAR-T28039-100mg100mg£2,079.00
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Further Information

Bioactivity:
Milfasartan is a potent, selective antagonist of AT1 receptor with oral activity. It markedly lowers the blood-pressure in conscious renal and spontaneously hypertensive rats.
CAS:
148564-47-0
Formula:
C30H30N6O3S
Molecular Weight:
554.67
Purity:
0.98
SMILES:
CCCCc1nc(C)n(Cc2sccc2C(=O)OC)c(=O)c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1

References

1. Soave R, Barzaghi M, Destro R. Progress in the understanding of drug-receptor interactions, part 2: experimental and theoretical electrostatic moments and interaction energies of an angiotensin II receptor antagonist (C30H30N6(O)3S). Chemistry. 2007;13(24):6942-56. PubMed PMID: 17539033. 2. Destro R, Soave R, Barzaghi M, Lo Presti L. Progress in the understanding of drug-receptor interactions, Part 1: experimental charge-density study of an angiotensin II receptor antagonist (C30H30N6O3S) at T = 17 K. Chemistry. 2005 Aug 5;11(16):4621-34. PubMed PMID: 15915518. 3. No?l B, Del Re G, Capone P, Brunner HR, Nussberger J. Clinical and hormonal effects of the new angiotensin II receptor antagonist LRB081. J Cardiovasc Pharmacol. 1996 Aug;28(2):252-8. PubMed PMID: 8856481. 4. Polidori C, Ciccocioppo R, Pompei P, Cirillo R, Massi M. Functional evidence for the ability of angiotensin AT1 receptor antagonists to cross the blood-brain barrier in rats. Eur J Pharmacol. 1996 Jul 4;307(3):259-67. PubMed PMID: 8836613.