TargetMol

MMRi64

Product Code:
 
TAR-T28078
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28078-1mg1mg£111.00
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TAR-T28078-5mg5mg£168.00
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TAR-T28078-10mg10mg£226.00
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TAR-T28078-25mg25mg£338.00
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TAR-T28078-50mg50mg£470.00
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TAR-T28078-100mg100mg£627.00
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Quantity:
TAR-T28078-500mg500mg£1,235.00
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This product comes from: United States.
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Further Information

Bioactivity:
MMRi64 is a specific inhibitor of Mdm2-MdmX E3 ligase activity. MMRi64 potently induces p53-dependent and p53-independent apoptosis in lymphoma cells.
CAS:
430458-66-5
Formula:
C22H17Cl2N3O
Molecular Weight:
410.3
Pathway:
Apoptosis
Purity:
0.98
SMILES:
Cc1ccnc(NC(c2cccc(Cl)c2Cl)c2ccc3cccnc3c2O)c1
Target:
Mdm2|p53|Apoptosis

References

1. Wu W, Xu C, Ling X, Fan C, Buckley BP, Chernov MV, Ellis L, Li F, Mu?oz IG, Wang X. Targeting RING domains of Mdm2-MdmX E3 complex activates apoptotic arm of the p53 pathway in leukemia/lymphoma cells. Cell Death Dis. 2015 Dec 31;6:e2035. doi: 10.1038/cddis.2015.358. PubMed PMID: 26720344; PubMed Central PMCID: PMC4720891.