TargetMol

Mps-BAY2b

Product Code:
 
TAR-T28091
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28091-5mg5mg£850.00
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Quantity:
TAR-T28091-50mg50mg£1,661.00
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Quantity:
TAR-T28091-100mg100mg£2,079.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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This product comes from: United States.
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Further Information

Bioactivity:
Mps-BAY2b is a novel MPS1 inhibitor.
CAS:
1263420-68-3
Formula:
C20H23N5O
Molecular Weight:
349.438
Purity:
0.98
SMILES:
CC(C)CNc1nccn2c(cnc12)-c1ccc(cc1)C(=O)NC1CC1

References

1. Uitdehaag JCM, de Man J, Willemsen-Seegers N, Prinsen MBW, Libouban MAA, Sterrenburg JG, de Wit JJP, de Vetter JRF, de Roos JADM, Buijsman RC, Zaman GJR. Target residence time-guided optimization on TTK kinase results in inhibitors with potent anti-proliferative activity. J Mol Biol. 2017 May 21. pii: S0022-2836(17)30243-7. doi: 10.1016/j.jmb.2017.05.014. [Epub ahead of print] PubMed PMID: 28539250. 2. Jema? M, Galluzzi L, Kepp O, Senovilla L, Brands M, Boemer U, Koppitz M, Lienau P, Prechtl S, Schulze V, Siemeister G, Wengner AM, Mumberg D, Ziegelbauer K, Abrieu A, Castedo M, Vitale I, Kroemer G. Characterization of novel MPS1 inhibitors with preclinical anticancer activity. Cell Death Differ. 2013 Nov;20(11):1532-45. doi: 10.1038/cdd.2013.105. Epub 2013 Aug 9. PubMed PMID: 23933817; PubMed Central PMCID: PMC3792427.