TargetMol

NC-1300-B

Product Code:
 
TAR-T28136
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28136-5mg5mg£850.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T28136-50mg50mg£1,661.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
Quantity:
TAR-T28136-100mg100mg£2,079.00
Special offer! Add £1 to your order to get a TargetMol CCK-8 Kit. Read more here.
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This product comes from: United States.
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Further Information

Bioactivity:
NC-1300-B is a proton pump. H(+)-K(+)-ATPase inhibition with NC-1300-B causes profound renal vasodilation and inhibition of renin release without affecting regulation of GFR.
CAS:
104340-52-5
Formula:
C17H19N3OS
Molecular Weight:
313.42
Purity:
0.98
SMILES:
CN(C)c1ccccc1CS(=O)c1nc2ccc(C)cc2[nH]1

References

1. Lin H, Young DB. Reduction in renin release and renal vascular resistance by H(+)-K(+)-ATPase inhibition. Am J Physiol. 1997 Sep;273(3 Pt 2):F457-62. PubMed PMID: 9321920. 2. Rhoden KJ, Tallini G, Douglas JS. H+-K+ ATPase inhibitors cause relaxation of guinea pig and human airway smooth muscle in vitro. J Pharmacol Exp Ther. 1996 Mar;276(3):897-903. PubMed PMID: 8786567. 3. McCabe RD, Young DB. Evidence of a K(+)-H(+)-ATPase in vascular smooth muscle cells. Am J Physiol. 1992 Jun;262(6 Pt 2):H1955-8. PubMed PMID: 1320341. 4. Okabe S, Akimoto Y, Yamasaki S, Nagai H. Effects of NC-1300-B, a new benzimidazole derivative, on hog gastric H+, K+-ATPase, gastric acid secretion and HCl.ethanol-induced gastric lesions in rats. Dig Dis Sci. 1988 Nov;33(11):1425-34. PubMed PMID: 2846250.