TargetMol

Nerispirdine HCl

Product Code:
 
TAR-T28160
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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TAR-T28160-5mg5mg£850.00
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TAR-T28160-50mg50mg£1,661.00
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TAR-T28160-100mg100mg£2,079.00
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Further Information

Bioactivity:
Nerispirdine is a acetylcholine release enhancer, sodium channel blocker and K(V) 2.1 channel blocker. Nerispirdine inhibits voltage-dependent Na(+) channel currents recorded from human SH-SY5Y cells with an IC(50) of 11.9 micromol/L when measured from a -70 mV holding potential. Nerispirdine also inhibits K(v)1.1 and K(v)1.2 with IC(50) values of 3.6 and 3.7 micromol/L, respectively.
CAS:
119229-64-0
Formula:
C17H19ClFN3
Molecular Weight:
319.81
Purity:
0.98
SMILES:
Cl.CCCN(c1ccncc1F)n1cc(C)c2ccccc12

References

1. Schofield J, Derdau V, Atzrodt J, Zane P, Guo Z, van Horn R, Czepczor V, Stoltz A, Pardon M. Effect of deuteration on metabolism and clearance of Nerispirdine (HP184) and AVE5638. Bioorg Med Chem. 2015 Jul 1;23(13):3831-42. doi: 10.1016/j.bmc.2015.03.065. PubMed PMID: 25900628. 2. Smith C, Kongsamut S, Wang H, Ji J, Kang J, Rampe D. In Vitro electrophysiological activity of nerispirdine, a novel 4-aminopyridine derivative. Clin Exp Pharmacol Physiol. 2009 Nov;36(11):1104-9. doi: 10.1111/j.1440-1681.2009.05200.x. PubMed PMID: 19413590. 3. Smith CP, Woods-Kettelberger AT, Corbett R, Chesson SM, Bores GM, Petko WW, Roehr JE, Kongsamut S. Serotonergic activity of HP 184: does spontaneous release have a role? Neurochem Res. 1996 May;21(5):575-83. PubMed PMID: 8726966. 4. Tang L, Kongsamut S. Frequency-dependent inhibition of neurotransmitter release by besipirdine and HP 184. Eur J Pharmacol. 1996 Apr 4;300(1-2):71-4. PubMed PMID: 8741167.