TargetMol

Nexopamil

Product Code:
 
TAR-T28164
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28164-1mg1mg£167.00
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TAR-T28164-5mg5mg£303.00
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TAR-T28164-10mg10mg£424.00
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TAR-T28164-25mg25mg£655.00
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TAR-T28164-50mg50mg£863.00
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TAR-T28164-100mg100mg£1,187.00
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TAR-T28164-500mg500mg£2,295.00
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Further Information

Bioactivity:
Nexopamil is a calcium channel antagonist and serotonin 2A receptor antagonist. Nexopamil inhibits 5-HT-induced mesangial cell contraction and proliferation.
CAS:
136033-49-3
Formula:
C24H40N2O3
Molecular Weight:
404.595
Pathway:
Neuroscience|Metabolism|Membrane transporter/Ion channel|GPCR/G Protein
Purity:
0.98
SMILES:
CCCCCCN(C)CCC[C@](C#N)(C(C)C)c1cc(OC)c(OC)c(OC)c1
Target:
5-HT Receptor|Calcium Channel

References

1. Nearing BD, Hutter JJ, Verrier RL. Potent antifibrillatory effect of combined blockade of calcium channels and 5-HT2 receptors with nexopamil during myocardial ischemia and reperfusion in dogs: comparison to diltiazem. J Cardiovasc Pharmacol. 1996 Jun;27(6):777-87. PubMed PMID: 8761843. 2. Park SJ, Lee JJ, Kirchengast M, Boulanger CM, Vanhoutte PM. The combined 5-HT2 receptor and calcium channel inhibitor LU49938 restores endothelium dependent responses in the regenerated endothelium of the porcine coronary artery. Cardiovasc Res. 1995 Jan;29(1):95-101. PubMed PMID: 7895245. 3. Montero A, Rodr?guez-L?pez A, Reverte M, L?pez-Novoa JM. The effect of LU-49938 (nexopamil) on the activation by serotonin of mesangial cells. Fundam Clin Pharmacol. 1995;9(2):175-80. PubMed PMID: 7628831. 4. Park SJ, Boulanger CM, Kirchengast M, Vanhoutte PM. Effects of the combined 5-hydroxytryptamine2 receptor and Ca2+ channel antagonist LU49938 on the responsiveness of isolated porcine coronary arteries with and without endothelium. J Cardiovasc Pharmacol. 1994 Sep;24(3):517-22. PubMed PMID: 7528308.