TargetMol

NIK-250

Product Code:
 
TAR-T28173
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28173-5mg5mg£1,010.00
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TAR-T28173-50mg50mg£1,982.00
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Quantity:
TAR-T28173-100mg100mg£2,560.00
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This product comes from: United States.
Typical lead time: 10-14 working days.
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Further Information

Bioactivity:
NIK-250 is a P-glycoprotein inhibitor. NIK250 could reverse multidrug resistance in human glioma cells.
CAS:
1000817-20-8
Formula:
C26H25N3O4S2
Molecular Weight:
507.62
Purity:
0.98
SMILES:
CC1=C(C(C2=C(C)SC=CS2)C(C(=O)OCc2ccncc2)=C(C)N1)C(=O)OCc1ccncc1

References

1. Tasaki Y, Nakagawa M, Ogata J, Kiue A, Tanimura H, Kuwano M, Nomura Y. Reversal by a dihydropyridine derivative of non-P-glycoprotein-mediated multidrug resistance in etoposide-resistant human prostatic cancer cell line. J Urol. 1995 Sep;154(3):1210-6. PubMed PMID: 7637090. 2. Abe T, Koike K, Ohga T, Kubo T, Wada M, Kohno K, Mori T, Hidaka K, Kuwano M. Chemosensitisation of spontaneous multidrug resistance by a 1,4-dihydropyridine analogue and verapamil in human glioma cell lines overexpressing MRP or MDR1. Br J Cancer. 1995 Aug;72(2):418-23. PubMed PMID: 7640227; PubMed Central PMCID: PMC2033970.