TargetMol

Niridazole

Product Code:
 
TAR-T28174
Product Group:
 
Inhibitors and Activators
Supplier:
 
TargetMol
Regulatory Status:
 
RUO
Shipping:
 
cool pack
Storage:
 
-20℃
1 / 1
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CodeSizePrice
TAR-T28174-1mg1mg£389.00
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TAR-T28174-5mg5mg£850.00
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TAR-T28174-10mg10mg£1,107.00
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TAR-T28174-25mg25mg£1,637.00
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TAR-T28174-50mg50mg£2,175.00
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TAR-T28174-100mg100mg£2,906.00
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Further Information

Bioactivity:
Niridazole can be used to treat schistosomiasis. Niridazole is rapidly concentrated in the parasite and inhibits oogenesis and spermatogenesis. It also inhibits the phosphofructokinase enzyme, leading to glycogen depletion and hepatic shift.
CAS:
61-57-4
Formula:
C6H6N4O3S
Molecular Weight:
214.2
Purity:
0.98
SMILES:
[O-][N+](=O)c1cnc(s1)N1CCNC1=O

References

1. Barat R, Srinatha A, Pandit JK, Ridhurkar D, Balasubramaniam J, Mittal N, Mishra DN. Niridazole biodegradable inserts for local long-term treatment of periodontitis: possible new life for an orphan drug. Drug Deliv. 2006 Sep-Oct;13(5):365-73. PubMed PMID: 16877312. 2. Fantel AG, Juchau MR, Tracy JW, Burroughs CJ, Person RE. Studies of mechanisms of niridazole-elicited embryotoxicity: evidence against a major role for covalent binding. Teratology. 1989 Jan;39(1):63-74. PubMed PMID: 2718141. 3. Wade WG, Addy M. Comparison of in vitro activity of niridazole, metronidazole and tetracycline against subgingival bacteria in chronic periodontitis. J Appl Bacteriol. 1987 Nov;63(5):455-7. PubMed PMID: 3440767. 4. Ma Z, Si BX, Liu YL, Huang LS. [Synthesis of acylates of niridazole and its analogs as schistosomicides]. Yao Xue Xue Bao. 1989;24(6):476-80. Chinese. PubMed PMID: 2609988.